Chemical | |
Description | A powerful inhibitor of hexosaminidases. Inhibits β-N-acetylglucosaminidases, enzymes which catalyse the hydrolysis of β-N-acetylglucosamine residues of lipid or protein-linked oligosaccharides, these are potentially useful targets for cancer chemotherapy. β-N-acetylglucosaminidases may be associated with the invasiveness of certain tumours and high activity levels of these enzymes have been found in serum and urine of patients with various malignancies. 6-Acetamido-6-deoxycastanospermine was tested against a panel of glycosidases and was found to be a very potent inhibitor of β-N-acetylglucosaminidases from human placenta (IC50 = 0.5 mM), bovine kidney (IC50 = 1.5 mM), jack bean (IC50 = 1.6 m M), porcine placenta (IC50 = 0.4 mM) and bovine epididymis (IC50 = 0.7 mM). Reference:Tett. Lett. 32, 6, 719-720. |
CAS Number | 134100-29-1 |
Formula | C10H18N2O4 |
Molecular Weight | 230.26 |
Alternative Name(s) | CastNAc |
Dextra was founded in 1989 in Reading (UK) to provide carbohydrate synthesis and analytical services to the scientific research community. Since then, the company has gained a world-wide reputation for the supply of rare sugars, oligosaccharides and chiral molecules for medical research, diagnostics and pharmaceutical applications. Dextra has successfully achieved ISO9001:2008 registration for its activities.